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Structural Basis for Recognition and Sequestration of UUU(OH) 3′ Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen
The nuclear phosphoprotein La was identified as an autoantigen in patients with systemic lupus erythematosus and Sjogren’s syndrome. La binds to and protects the UUU(OH) 3′ terminii of nascent RNA polymerase III transcripts from exonuclease digestion. We report the 1.85 Å crystal structure of the N-...
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| Veröffentlicht in: | Mol Cell |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689297/ https://ncbi.nlm.nih.gov/pubmed/16387655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.10.027 |
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