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Two-Repeat Human Telomeric d(TAGGGTTAGGGT) Sequence Forms Interconverting Parallel and Antiparallel G-Quadruplexes in Solution: Distinct Topologies, Thermodynamic Properties, and Folding/Unfolding Kinetics

We demonstrate by NMR that the two-repeat human telomeric sequence d(TAGGGTTAGGGT) can form both parallel and antiparallel G-quadruplex structures in K(+)-containing solution. Both structures are dimeric G-quadruplexes involving three stacked G-tetrads. The sequence d(TAGGGUTAGGGT), containing a sin...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Phan, Anh Tuân, Patel, Dinshaw J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693644/
https://ncbi.nlm.nih.gov/pubmed/14653736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja037616j
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