Structural Insights into RNA Recognition by the Alternate-splicing Regulator CUG Binding Protein 1

CUG binding protein 1 (CUGBP1) regulates multiple aspects of nuclear and cytoplasmic mRNA processing, with implications for onset of myotonic dystrophy. CUGBP1 harbors three RRM domains and preferentially targets UGU-rich mRNA elements. We report on crystal structures of CUGBP1 RRM1 and tandem RRM1/...

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Huvudupphovsmän: Teplova, Marianna, Song, Jikui, Gaw, Hai Yan, Teplov, Alexei, Patel, Dinshaw J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381513/
https://ncbi.nlm.nih.gov/pubmed/20947024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.06.018
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