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Structural Insights into RNA Recognition by the Alternate-splicing Regulator CUG Binding Protein 1
CUG binding protein 1 (CUGBP1) regulates multiple aspects of nuclear and cytoplasmic mRNA processing, with implications for onset of myotonic dystrophy. CUGBP1 harbors three RRM domains and preferentially targets UGU-rich mRNA elements. We report on crystal structures of CUGBP1 RRM1 and tandem RRM1/...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381513/ https://ncbi.nlm.nih.gov/pubmed/20947024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.06.018 |
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