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Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation
DNMT1, the major maintenance DNA methyltransferase in animals, helps to regulate gene expression, genome imprinting, and X-chromosome inactivation. We report on the crystal structure of a productive covalent mouse DNMT1(731-1602)–DNA complex containing a central hemimethylated CpG site. The methyl g...
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| Udgivet i: | Science |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4693633/ https://ncbi.nlm.nih.gov/pubmed/22323818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214453 |
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