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Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation
UHRF1 plays multiple roles in regulating DNMT1-mediated DNA methylation maintenance during DNA replication. The UHRF1 C-terminal RING finger functions as an ubiquitin E3 ligase to establish histone H3 ubiquitination at Lys18 and/or Lys23, which is subsequently recognized by DNMT1 to promote its loca...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5887372/ https://ncbi.nlm.nih.gov/pubmed/29471350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky104 |
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