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Structural Basis for Recognition and Sequestration of UUU(OH) 3′ Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen
The nuclear phosphoprotein La was identified as an autoantigen in patients with systemic lupus erythematosus and Sjogren’s syndrome. La binds to and protects the UUU(OH) 3′ terminii of nascent RNA polymerase III transcripts from exonuclease digestion. We report the 1.85 Å crystal structure of the N-...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689297/ https://ncbi.nlm.nih.gov/pubmed/16387655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.10.027 |
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