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Translesion polymerases drive microhomology-mediated break-induced replication leading to complex chromosomal rearrangements
Complex genomic rearrangements (CGRs) are a hallmark of many human diseases. Recently, CGRs were suggested to result from microhomology-mediated break-induced replication (MMBIR), a replicative mechanism involving template switching at positions of microhomology. Currently, the cause of MMBIR and th...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4688117/ https://ncbi.nlm.nih.gov/pubmed/26669261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.041 |
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