Migrating bubble during break-induced replication drives conservative DNA synthesis

The repair of chromosomal double strand breaks (DSBs) is crucial in the maintenance of genomic integrity. However, the repair of DSBs can also destabilize the genome by causing mutations and chromosomal rearrangements, the driving forces for carcinogenesis and hereditary diseases. Break induced repl...

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Hlavní autoři: Saini, Natalie, Ramakrishnan, Sreejith, Elango, Rajula, Ayyar, Sandeep, Zhang, Yu, Deem, Angela, Ira, Grzegorz, Haber, James E., Lobachev, Kirill S., Malkova, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804423/
https://ncbi.nlm.nih.gov/pubmed/24025772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12584
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