α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

Peptides can be developed as effective antagonists of protein-protein interactions, but conventional peptides (i.e., oligomers of L-α-amino acids) suffer from significant limitations in vivo. Short half-lives due to rapid proteolytic degradation and an inability to cross cell membranes often preclud...

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Publicado en:J Am Chem Soc
Main Authors: Checco, James W., Lee, Erinna F., Evangelista, Marco, Sleebs, Nerida J., Rogers, Kelly, Pettikiriarachchi, Anne, Kershaw, Nadia J., Eddinger, Geoffrey A., Belair, David G., Wilson, Julia L., Eller, Chelcie H., Raines, Ronald T., Murphy, William L., Smith, Brian J., Gellman, Samuel H., Fairlie, W. Douglas
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687753/
https://ncbi.nlm.nih.gov/pubmed/26317395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05896
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