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Antimicrobial Synergy of a Ribonuclease and a Peptide Secreted by Human Cells

LL-37 is a secretory peptide that has antimicrobial activity. Ribonuclease 1 (RNase 1) is a secretory enzyme that is not cytotoxic. We find that human LL-37 and human RNase 1 can act synergistically to kill Gram-negative bacterial cells. In the presence of nontoxic concentrations of LL-37, RNase 1 i...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Eller, Chelcie H., Raines, Ronald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669604/
https://ncbi.nlm.nih.gov/pubmed/33054163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00594
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