Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1

[Image: see text] Pancreatic-type ribonucleases are secretory enzymes that catalyze the cleavage of RNA. Recent efforts have endowed the homologues from cow (RNase A) and human (RNase 1) with toxicity for cancer cells, leading to a clinical trial. The basis for the selective toxicity of ribonuclease...

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Publicat a:ACS Cent Sci
Autors principals: Eller, Chelcie H., Chao, Tzu-Yuan, Singarapu, Kiran K., Ouerfelli, Ouathek, Yang, Guangbin, Markley, John L., Danishefsky, Samuel J., Raines, Ronald T.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571170/
https://ncbi.nlm.nih.gov/pubmed/26405690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00164
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