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Contribution of Electrostatics to the Binding of Pancreatic-Type Ribonucleases to Membranes
Pancreatic-type ribonucleases show clinical promise as chemotherapeutic agents, but are limited in efficacy by the inefficiency of their uptake by human cells. Cellular uptake can be increased by the addition of positive charges to the surface of ribonucleases, either by site-directed mutagenesis or...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839965/ https://ncbi.nlm.nih.gov/pubmed/23947917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400619m |
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