α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

Peptides can be developed as effective antagonists of protein-protein interactions, but conventional peptides (i.e., oligomers of L-α-amino acids) suffer from significant limitations in vivo. Short half-lives due to rapid proteolytic degradation and an inability to cross cell membranes often preclud...

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Publié dans:J Am Chem Soc
Auteurs principaux: Checco, James W., Lee, Erinna F., Evangelista, Marco, Sleebs, Nerida J., Rogers, Kelly, Pettikiriarachchi, Anne, Kershaw, Nadia J., Eddinger, Geoffrey A., Belair, David G., Wilson, Julia L., Eller, Chelcie H., Raines, Ronald T., Murphy, William L., Smith, Brian J., Gellman, Samuel H., Fairlie, W. Douglas
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687753/
https://ncbi.nlm.nih.gov/pubmed/26317395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05896
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