Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal

Formative research suggests that a human embryonic stem cell-specific alternative splicing gene regulatory network, which is repressed by Muscleblind-like (MBNL) RNA binding proteins, is involved in cell reprogramming. In this study, RNA sequencing, splice isoform-specific quantitative RT-PCR, lenti...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Holm, Frida, Hellqvist, Eva, Mason, Cayla N., Ali, Shawn A., Delos-Santos, Nathaniel, Barrett, Christian L., Chun, Hye-Jung, Minden, Mark D., Moore, Richard A., Marra, Marco A., Runza, Valeria, Frazer, Kelly A., Sadarangani, Anil, Jamieson, Catriona H. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687548/
https://ncbi.nlm.nih.gov/pubmed/26621726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506943112
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