ADAR1 Activation Drives Leukemia Stem Cell Self-renewal by Impairing Let-7 Biogenesis

Post-transcriptional adenosine-to-inosine RNA editing mediated by adenosine deaminase acting on RNA1 (ADAR1) promotes cancer progression and therapeutic resistance. However, ADAR1 editase-dependent mechanisms governing leukemia stem cell (LSC) generation have not been elucidated. In blast crisis chr...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Zipeto, Maria Anna, Court, Angela C., Sadarangani, Anil, Delos-Santos, Nathaniel P., Balaian, Larisa, Chun, Hye-Jung, Pineda, Gabriel, Morris, Sheldon R., Mason, Cayla N., Geron, Ifat, Barrett, Christian, Goff, Daniel J., Wall, Russell, Pellecchia, Maurizio, Minden, Mark, Frazer, Kelly A., Marra, Marco A., Crews, Leslie A., Jiang, Qingfei, Jamieson, Catriona H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975616/
https://ncbi.nlm.nih.gov/pubmed/27292188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.05.004
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