RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML

Age-related human hematopoietic stem cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoietic progenitor cells into therapy-resistant leukemia stem cells (LSC) in secondary acute myeloid leukemia (sAML). While acquisition of clonal DNA mutations have been l...

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Publicado no:Cell Stem Cell
Main Authors: Crews, Leslie A., Balaian, Larisa, Delos Santos, Nathaniel P., Leu, Heather S., Court, Angela C., Lazzari, Elisa, Sadarangani, Anil, Zipeto, Maria A., La Clair, James J., Villa, Reymundo, Kulidjian, Anna, Storb, Rainer, Morris, Sheldon R., Ball, Edward D., Burkart, Michael D., Jamieson, Catriona H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097015/
https://ncbi.nlm.nih.gov/pubmed/27570067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.08.003
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