RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML

Age-related human hematopoietic stem cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoietic progenitor cells into therapy-resistant leukemia stem cells (LSC) in secondary acute myeloid leukemia (sAML). While acquisition of clonal DNA mutations have been l...

詳細記述

保存先:
書誌詳細
出版年:Cell Stem Cell
主要な著者: Crews, Leslie A., Balaian, Larisa, Delos Santos, Nathaniel P., Leu, Heather S., Court, Angela C., Lazzari, Elisa, Sadarangani, Anil, Zipeto, Maria A., La Clair, James J., Villa, Reymundo, Kulidjian, Anna, Storb, Rainer, Morris, Sheldon R., Ball, Edward D., Burkart, Michael D., Jamieson, Catriona H. M.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097015/
https://ncbi.nlm.nih.gov/pubmed/27570067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.08.003
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