Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2

Translational control of gene expression plays a key role during the early phases of embryonic development. Here we describe a transcriptional regulator of mouse embryonic stem cells (mESCs), Yin-yang 2 (YY2), that is controlled by the translation inhibitors, Eukaryotic initiation factor 4E-binding...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tahmasebi, Soroush, Jafarnejad, Seyed Mehdi, Tam, Ingrid S., Gonatopoulos-Pournatzis, Thomas, Matta-Camacho, Edna, Tsukumo, Yoshinori, Yanagiya, Akiko, Li, Wencheng, Atlasi, Yaser, Caron, Maxime, Braunschweig, Ulrich, Pearl, Dana, Khoutorsky, Arkady, Gkogkas, Christos G., Nadon, Robert, Bourque, Guillaume, Yang, Xiang-Jiao, Tian, Bin, Stunnenberg, Hendrik G., Yamanaka, Yojiro, Blencowe, Benjamin J., Giguère, Vincent, Sonenberg, Nahum
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098618/
https://ncbi.nlm.nih.gov/pubmed/27791185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615540113
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