Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation in the development of diabetic cardiomyopathy. T1D was induced in transgenic mice overexpressing calpastatin, in mic...

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Ni, Rui, Zheng, Dong, Xiong, Sidong, Hill, David J., Sun, Tao, Gardiner, Richard B., Fan, Guo-Chang, Lu, Yanrong, Abel, E. Dale, Greer, Peter A., Peng, Tianqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2016
Schlagworte:
Complications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686953/
https://ncbi.nlm.nih.gov/pubmed/26470784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0963
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