Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation

BACKGROUND: Our recent study has demonstrated that inhibition of calpain by transgenic over-expression of calpastatin reduces myocardial pro-inflammatory response and dysfunction in endotoxemia. However, the underlying mechanisms remain to be determined. In this study, we employed cardiomyocyte-spec...

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Bibliografische gegevens
Gepubliceerd in:Circ Heart Fail
Hoofdauteurs: Ni, Rui, Zheng, Dong, Wang, Qiang, Yu, Yong, Chen, Ruizhen, Sun, Tao, Wang, Wang, Fan, Guo-Chang, Greer, Peter A., Gardiner, Richard B., Peng, Tianqing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573911/
https://ncbi.nlm.nih.gov/pubmed/26246018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002383
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