Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation in the development of diabetic cardiomyopathy. T1D was induced in transgenic mice overexpressing calpastatin, in mic...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Ni, Rui, Zheng, Dong, Xiong, Sidong, Hill, David J., Sun, Tao, Gardiner, Richard B., Fan, Guo-Chang, Lu, Yanrong, Abel, E. Dale, Greer, Peter A., Peng, Tianqing
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2016
Assuntos:
Complications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686953/
https://ncbi.nlm.nih.gov/pubmed/26470784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0963
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares