Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

Diabetes and obesity are prevalent in westernized countries. In both conditions, excessive fatty acid uptake by cardiomyocytes induces cardiac lipotoxicity, an important mechanism contributing to diabetic cardiomyopathy. This study investigated the effect of calpain disruption on cardiac lipotoxicit...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Li, Shengcun, Zhang, Lulu, Ni, Rui, Cao, Ting, Zheng, Dong, Xiong, Sidong, Greer, Peter A., Fan, Guo-Chang, Peng, Tianqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066874/
https://ncbi.nlm.nih.gov/pubmed/27523632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.08.005
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