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Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress
Diabetes and obesity are prevalent in westernized countries. In both conditions, excessive fatty acid uptake by cardiomyocytes induces cardiac lipotoxicity, an important mechanism contributing to diabetic cardiomyopathy. This study investigated the effect of calpain disruption on cardiac lipotoxicit...
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| Udgivet i: | Biochim Biophys Acta |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5066874/ https://ncbi.nlm.nih.gov/pubmed/27523632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.08.005 |
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