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Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation

Both calpain activation and endoplasmic reticulum (ER) stress are implicated in ischemic heart injury. However, the role of calpain in ER stress remains largely elusive. This study investigated whether calpain activation causes ER stress, thereby mediating cardiomyocyte apoptosis in an in vitro mode...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Zheng, Dong, Wang, Grace, Li, Shuai, Fan, Guo-Chang, Peng, Tianqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418534/
https://ncbi.nlm.nih.gov/pubmed/25660447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.01.019
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