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Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8
The full enzymatic activity of the cullin-RING ubiquitin ligases (CRLs) requires a ubiquitin-like protein (that is, Nedd8) modification. By deamidating Gln40 of Nedd8 to glutamate (Q40E), the bacterial cycle-inhibiting factor (Cif) family is able to inhibit CRL E3 activities, thereby interfering wit...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686759/ https://ncbi.nlm.nih.gov/pubmed/26632597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10053 |
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