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Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 by a Bacterial Effector Family
A family of bacterial effectors including CHBP from Burkholderia pseudomallei and Cif from Enteropathogenic E. Coli (EPEC) adopt a functionally important papain-like hydrolytic fold. Here, CHBP is shown to be a potent inhibitor of the eukaryotic ubiquitination pathway. CHBP acts as a deamidase that...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031172/ https://ncbi.nlm.nih.gov/pubmed/20688984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1193844 |
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