The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin

High-resolution mass spectrometry maps the cytotoxic T lymphocyte (CTL) proteome and the impact of mammalian target of rapamycin complex 1 (mTORC1) on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes and mTORC1 selectively repressed and promoted expression of subset of CTL...

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Pubblicato in:Nat Immunol
Autori principali: Hukelmann, Jens L., Anderson, Karen E., Sinclair, Linda V., Grzes, Katarzyna M., Murillo, Alejandro Brenes, Hawkins, Phillip T., Stephens, Len R., Lamond, Angus I., Cantrell, Doreen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685757/
https://ncbi.nlm.nih.gov/pubmed/26551880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3314
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