Multibatch TMT Reveals False Positives, Batch Effects and Missing Values

Multiplexing strategies for large-scale proteomic analyses have become increasingly prevalent, tandem mass tags (TMT) in particular. Here we used a large iPSC proteomic experiment with twenty-four 10-plex TMT batches to evaluate the effect of integrating multiple TMT batches within a single analysis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Proteomics
Prif Awduron: Brenes, Alejandro, Hukelmann, Jens, Bensaddek, Dalila, Lamond, Angus I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773557/
https://ncbi.nlm.nih.gov/pubmed/31332098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001472
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