Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53

Colorectal peritoneal carcinomatosis (CPC) exhibits severe tumor hypoxia, leading to drug resistance and disease aggressiveness. This study demonstrates that the combination of the chemotherapeutic agent mitomycin C with the proteasome inhibitor bortezomib induced synergistic cytotoxicity and apopto...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Res
Asıl Yazarlar: Song, Xinxin, Dilly, Ashok-Kumar, Choudry, Haroon Asif, Bartlett, David L., Kwon, Yong Tae, Lee, Yong J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684998/
https://ncbi.nlm.nih.gov/pubmed/26354682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0237
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