CBIO-15. MDM2 INHIBITOR SYNERGY WITH BCL-XL INHIBITION FOR p53 WILD TYPE GLIOBLASTOMA

BACKGROUND: Glioblastoma (GBM) is an infiltrative, uniformly fatal brain tumor, treated with surgery, radiation, and Temozolomide (TMZ). Chemoradiation induces a senescent-like phenotype, which contributes to disease recurrence. We recently found that, radiated GBM cells can be eliminated by inhibit...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Rahman, Masum, Olson, Ian E, Saber, Rehan, Carlstrom, Lucas P, Jhang, Jibo, Brown, Desmond, Rajani, Karishma, Sarkaria, Jann, Parney, Ian, Burns, Terry C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650374/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.075
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