Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53

Colorectal peritoneal carcinomatosis (CPC) exhibits severe tumor hypoxia, leading to drug resistance and disease aggressiveness. This study demonstrates that the combination of the chemotherapeutic agent mitomycin C with the proteasome inhibitor bortezomib induced synergistic cytotoxicity and apopto...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Res
Huvudupphovsmän: Song, Xinxin, Dilly, Ashok-Kumar, Choudry, Haroon Asif, Bartlett, David L., Kwon, Yong Tae, Lee, Yong J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684998/
https://ncbi.nlm.nih.gov/pubmed/26354682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0237
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