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Chemoproteomics reveals novel protein and lipid kinase targets of clinical CDK4/6 inhibitors in lung cancer

Several selective CDK4/6 inhibitors are in clinical trials for non-small cell lung cancer (NSCLC). Palbociclib (PD0332991) is included in the phase II/III Lung-MAP trial for squamous cell lung carcinoma (LUSQ). We noted differential cellular activity between palbociclib and the structurally related...

詳細記述

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書誌詳細
出版年:ACS Chem Biol
主要な著者: Sumi, Natalia J., Kuenzi, Brent M., Knezevic, Claire E., Rix, Lily L. Remsing, Rix, Uwe
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684772/
https://ncbi.nlm.nih.gov/pubmed/26390342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00368
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