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Chemoproteomics reveals novel protein and lipid kinase targets of clinical CDK4/6 inhibitors in lung cancer

Several selective CDK4/6 inhibitors are in clinical trials for non-small cell lung cancer (NSCLC). Palbociclib (PD0332991) is included in the phase II/III Lung-MAP trial for squamous cell lung carcinoma (LUSQ). We noted differential cellular activity between palbociclib and the structurally related...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Sumi, Natalia J., Kuenzi, Brent M., Knezevic, Claire E., Rix, Lily L. Remsing, Rix, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684772/
https://ncbi.nlm.nih.gov/pubmed/26390342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00368
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