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Disparate Mutations Confer Therapeutic Gain of Hsp104 Function
Hsp104, a protein disaggregase from yeast, can be engineered and potentiated to counter TDP-43, FUS, or α-synuclein misfolding and toxicity implicated in neurodegenerative disease. Here, we reveal that extraordinarily disparate mutations potentiate Hsp104. Remarkably, diverse single missense mutatio...
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| Udgivet i: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684741/ https://ncbi.nlm.nih.gov/pubmed/26441009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00765 |
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