Therapeutic genetic variation revealed in diverse Hsp104 homologs

The AAA+ protein disaggregase, Hsp104, increases fitness under stress by reversing stress-induced protein aggregation. Natural Hsp104 variants might exist with enhanced, selective activity against neurodegenerative disease substrates. However, natural Hsp104 variation remains largely unexplored. Her...

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Bibliographic Details
Published in:eLife
Main Authors: March, Zachary M, Sweeney, Katelyn, Kim, Hanna, Yan, Xiaohui, Castellano, Laura M, Jackrel, Meredith E, Lin, JiaBei, Chuang, Edward, Gomes, Edward, Willicott, Corey W, Michalska, Karolina, Jedrzejczak, Robert P, Joachimiak, Andrzej, Caldwell, Kim A, Caldwell, Guy A, Shalem, Ophir, Shorter, James
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785292/
https://ncbi.nlm.nih.gov/pubmed/33319748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57457
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