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De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
Despite efforts for over 25 years, de novo protein design has not succeeded in achieving the TIM-barrel fold. Here we describe the computational design of 4-fold symmetrical (β/α)(8)-barrels guided by geometrical and chemical principles. Experimental characterization of 33 designs revealed the impor...
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| Опубликовано в: : | Nat Chem Biol |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684731/ https://ncbi.nlm.nih.gov/pubmed/26595462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1966 |
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