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De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

Despite efforts for over 25 years, de novo protein design has not succeeded in achieving the TIM-barrel fold. Here we describe the computational design of 4-fold symmetrical (β/α)(8)-barrels guided by geometrical and chemical principles. Experimental characterization of 33 designs revealed the impor...

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Detalles Bibliográficos
Publicado en:Nat Chem Biol
Main Authors: Huang, Po-Ssu, Feldmeier, Kaspar, Parmeggiani, Fabio, Velasco, D. Alejandro Fernandez, Höcker, Birte, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684731/
https://ncbi.nlm.nih.gov/pubmed/26595462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1966
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