Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis

Epidermal growth factor receptor (EGFR) and ERBB3 have been implicated in hepatocellular carcinogenesis (HCC). However, it is not known whether altering the activity of either EGFR or ERBB3 affects HCC development. We now show that Egfr(Dsk5) mutant mice, which have a gain-of-function allele that in...

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Bibliografiset tiedot
Julkaisussa:Am J Physiol Gastrointest Liver Physiol
Päätekijät: Scheving, Lawrence A., Zhang, Xiuqi, Stevenson, Mary C., Weintraub, Michael A., Abbasi, Annam, Clarke, Andrea M., Threadgill, David W., Russell, William E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2015
Aiheet:
Liver and Biliary Tract Physiology/Pathophysiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683301/
https://ncbi.nlm.nih.gov/pubmed/26492920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00089.2015
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