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Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous ligands bile acids. Mice with whole body FXR deficiency develop liver tumors spontaneously, but the underlying mechanism is unclear. Moreover, it is unknown whether FXR deficiency in liver alone serves as a tu...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Kong, Bo, Zhu, Yan, Li, Guodong, Williams, Jessica A., Buckley, Kyle, Tawfik, Ossama, Luyendyk, James P., Guo, Grace L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773826/
https://ncbi.nlm.nih.gov/pubmed/26744468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00134.2015
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