Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous ligands bile acids. Mice with whole body FXR deficiency develop liver tumors spontaneously, but the underlying mechanism is unclear. Moreover, it is unknown whether FXR deficiency in liver alone serves as a tu...

Full description

Saved in:
Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Kong, Bo, Zhu, Yan, Li, Guodong, Williams, Jessica A., Buckley, Kyle, Tawfik, Ossama, Luyendyk, James P., Guo, Grace L.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
Subjects:
Liver and Biliary Tract Physiology/Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773826/
https://ncbi.nlm.nih.gov/pubmed/26744468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00134.2015
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items