Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis

Epidermal growth factor receptor (EGFR) and ERBB3 have been implicated in hepatocellular carcinogenesis (HCC). However, it is not known whether altering the activity of either EGFR or ERBB3 affects HCC development. We now show that Egfr(Dsk5) mutant mice, which have a gain-of-function allele that in...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Scheving, Lawrence A., Zhang, Xiuqi, Stevenson, Mary C., Weintraub, Michael A., Abbasi, Annam, Clarke, Andrea M., Threadgill, David W., Russell, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Liver and Biliary Tract Physiology/Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683301/
https://ncbi.nlm.nih.gov/pubmed/26492920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00089.2015
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