Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis

Epidermal growth factor receptor (EGFR) and ERBB3 have been implicated in hepatocellular carcinogenesis (HCC). However, it is not known whether altering the activity of either EGFR or ERBB3 affects HCC development. We now show that Egfr(Dsk5) mutant mice, which have a gain-of-function allele that in...

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Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Scheving, Lawrence A., Zhang, Xiuqi, Stevenson, Mary C., Weintraub, Michael A., Abbasi, Annam, Clarke, Andrea M., Threadgill, David W., Russell, William E.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
Subjects:
Liver and Biliary Tract Physiology/Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683301/
https://ncbi.nlm.nih.gov/pubmed/26492920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00089.2015
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