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Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes

The farnesoid X receptor (FXR) is a ligand (bile acid)-dependent nuclear receptor that regulates target genes involved in every aspect of bile acid homeostasis. Upon binding of ligand, FXR recruits an array of coactivators and associated proteins, some of which have intrinsic enzymatic activity that...

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Detalhes bibliográficos
Main Authors: Balasubramaniyan, Natarajan, Ananthanarayanan, Meena, Suchy, Frederick J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362072/
https://ncbi.nlm.nih.gov/pubmed/22345554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00441.2011
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