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Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes
The farnesoid X receptor (FXR) is a ligand (bile acid)-dependent nuclear receptor that regulates target genes involved in every aspect of bile acid homeostasis. Upon binding of ligand, FXR recruits an array of coactivators and associated proteins, some of which have intrinsic enzymatic activity that...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362072/ https://ncbi.nlm.nih.gov/pubmed/22345554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00441.2011 |
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