Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes

The farnesoid X receptor (FXR) is a ligand (bile acid)-dependent nuclear receptor that regulates target genes involved in every aspect of bile acid homeostasis. Upon binding of ligand, FXR recruits an array of coactivators and associated proteins, some of which have intrinsic enzymatic activity that...

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Detaylı Bibliyografya
Asıl Yazarlar: Balasubramaniyan, Natarajan, Ananthanarayanan, Meena, Suchy, Frederick J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2012
Konular:
Liver and Biliary Tract
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362072/
https://ncbi.nlm.nih.gov/pubmed/22345554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00441.2011
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