Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

Recent studies have implicated a pathogenic role for matrix metalloproteinases 9 (MMP-9) in inflammatory bowel disease. Although loss of epithelial barrier function has been shown to be a key pathogenic factor for the development of intestinal inflammation, the role of MMP-9 in intestinal barrier fu...

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Publicado en:Am J Physiol Gastrointest Liver Physiol
Autores principales: Nighot, Prashant, Al-Sadi, Rana, Rawat, Manmeet, Guo, Shuhong, Watterson, D. Martin, Ma, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2015
Materias:
Inflammation, Immunity, and Infection
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683300/
https://ncbi.nlm.nih.gov/pubmed/26514773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00256.2015
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