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TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Tumor necrosis factor (TNF)-α, a key mediator of intestinal inflammation, causes an increase in intestinal epithelial tight junction (TJ) permeability by activating myosin light chain kinase (MLCK; official name MYLK3) gene. However, the precise signaling cascades that mediate the TNF-α–induced acti...

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Publicat a:Am J Pathol
Autors principals: Al-Sadi, Rana, Guo, Shuhong, Ye, Dongmei, Rawat, Manmeet, Ma, Thomas Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861759/
https://ncbi.nlm.nih.gov/pubmed/26948423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.12.016
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