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Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR-4 signal transduction pathway activation of FAK and MyD88

Gut-derived bacterial lipopolysaccharides (LPS) play an essential role in inducing intestinal and systemic inflammatory responses and have been implicated as a pathogenic factor of necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). The defective intestinal tight junction (TJ) barr...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Guo, Shuhong, Nighot, Meghali, Al-Sadi, Rana, Alhmoud, Tarik, Nighot, Prashant, Ma, Thomas Y.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637237/
https://ncbi.nlm.nih.gov/pubmed/26466961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402598
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