ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

Epithelial–mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis progression. EMT often associates with increased transforming growth factor-β (TGF-β) signaling, and TGF-β drives EMT, in part through Smad-media...

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Udgivet i:PLoS Biol
Main Authors: Muthusamy, Baby Periyanayaki, Budi, Erine H., Katsuno, Yoko, Lee, Matthew K., Smith, Susan M., Mirza, Amer M., Akhurst, Rosemary J., Derynck, Rik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682977/
https://ncbi.nlm.nih.gov/pubmed/26680585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002325
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