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Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice

Angelman syndrome (AS) is a neurodevelopmental disorder associated with developmental delay, lack of speech, motor dysfunction, and epilepsy. In the majority of the patients, AS is caused by the deletion of small portions of maternal chromosome 15 harboring the UBE3A gene. This results in a lack of...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Santini, Emanuela, Turner, Kathryn L., Ramaraj, Akila B., Murphy, Michael P., Klann, Eric, Kaphzan, Hanoch
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682786/
https://ncbi.nlm.nih.gov/pubmed/26658871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2246-15.2015
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