Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

Well-balanced mitochondrial fission and fusion processes are essential for nervous system development. Loss of function of the main mitochondrial fission mediator, dynamin-related protein 1 (Drp1), is lethal early during embryonic development or around birth, but the role of mitochondrial fission in...

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Опубликовано в: :Cell Death Differ
Главные авторы: Oettinghaus, B, Schulz, J M, Restelli, L M, Licci, M, Savoia, C, Schmidt, A, Schmitt, K, Grimm, A, Morè, L, Hench, J, Tolnay, M, Eckert, A, D'Adamo, P, Franken, P, Ishihara, N, Mihara, K, Bischofberger, J, Scorrano, L, Frank, S
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815974/
https://ncbi.nlm.nih.gov/pubmed/25909888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.39
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