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Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts

How mitochondrial dynamism (fission and fusion) affects mitochondrial quality control is unclear. We uncovered distinct effects on mitophagy of inhibiting Drp1-mediated mitochondrial fission versus mitofusin-mediated mitochondrial fusion. Conditional cardiomyocyte-specific Drp1 ablation evoked mitoc...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Song, Moshi, Mihara, Katsuyoshi, Chen, Yun, Scorrano, Luca, Dorn, Gerald W
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318753/
https://ncbi.nlm.nih.gov/pubmed/25600785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.12.011
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